Further Aspects of Lymphosarcoma in Xenopus (the South African Clawed Toad).
نویسنده
چکیده
sarcoma.s in Triturus cristatus, and the experiments result ing in the induction of lymphosarcoma in Xenopus laevi@ laevis (2) have a number of similarities. Methylchol anth.rene as carcinogen and urethan as anesthetic are common features of these experiments, but whereas spontaneous lymphoid tumors are known in Xenopus, none have yet been reported in Triturus (1). Thus, the role of urethan in Leone's experiments would seem to have been cocarcinogenic, whereas in the Xenopus experi ments the tumor-augmenting property of urethan (14) may have played a part. The first part of this article is about two groups of experiments designed to test the role of urethan in carcinogenesis in Xenopus. Both spontaneouslyand chemically-induced lympho sarcomas have been found to be readily transplantable by homografting tumor fragments (3, 9) ; the implantation of histologically normal tissues has also led to lymphosar coma formation in Xenopus (5). The second part of the article deals with experiments involving the transfer of histologically-normal tissues from tumor-bearing animals, and the transfer of tumors to Xenopus tadpoles or to the eyes of adult Xenopus.
منابع مشابه
The Transmission of Lymphosarcoma in Xenopus laevis, the South African Clawed Toad1
The Xenopus lymphosarcoma agent is resistant to freezingthawing, freeze-drying, and antibiotics, but sensitive to heat, ether, and chloroform. It passes a 100-nui filter, and remains in the supernatant fluid following centrifugaron at 30,000 X g for 1 hr. The agent is passed from toad to toad through the water in which the Xenopus live. Phytohemagglutinin injection did not alter the latent peri...
متن کاملThe transmission of lymphosarcoma in Xenopus laevis, the South African clawed toad.
The Xenopus lymphosarcoma agent is resistant to freezingthawing, freeze-drying, and antibiotics, but sensitive to heat, ether, and chloroform. It passes a 100-nui filter, and remains in the supernatant fluid following centrifugaron at 30,000 X g for 1 hr. The agent is passed from toad to toad through the water in which the Xenopus live. Phytohemagglutinin injection did not alter the latent peri...
متن کاملThe Incidence of Pathologic Abnormalities, including Spontaneous Lymphosarcomas, in a Laboratory Stock of Xenopus (the South African Clawed Toad).
متن کامل
Cell-free extracts of eggs of the South African clawed toad Xenopus faevis
Cell-free extracts of eggs of the South African clawed toad Xenopus faevis support complete chromosome replication under normal cell cycle control (Blow and Laskey 1986). Apart from a similar system derived from embryos of the fruit fly Drosophifa mefanogaster (Crevel and Cotterill 1991), it is currently the only eukaryotic cell-free system that supports efficient chromosome replication in vitr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 25 شماره
صفحات -
تاریخ انتشار 1965